INSPIRE Summer School on Cardiovascular Safety Pharmacology and Cardio-Oncology

INSPIRE offers an intensive 5-days programme with a particular focus on Cardiovascular Safety Pharmacology and Cardio-Oncology.

Description

A 5-day program on Cardiovascular Safety Pharmacology and Cardio-Oncology consisting of theoretical lectures complemented by hands-on sessions in associated technologies. This course is a continuation of the EU-funded collaborative training network in safety pharmacology INSPIRE (www.inspire-safety-pharmacology.eu), which in the past three years has built a training program benefiting from the academic, industrial, and clinical perspectives by exploring the latest technological capabilities to address emerging cardiovascular and cardio-oncology safety concerns.

Program

The programme starts with a refresher on cardiovascular physiology and pathophysiology. Next, speakers from leading pharma companies will provide insight in the process of drug development and the importance of clinical safety. The regulatory landscape of drug development and safety evaluation will be elaborated, as well as a description of key methods implemented in Safety Pharmacology to identify adverse effects of drug candidates early on. A few case studies of failed drug candidates will be discussed as well. Further, clinical cases of drug-related cardiovascular complications presented by cardiologists will provide a wider perspective on the topic. More specifically, the discipline of cardio-oncology will be discussed in detail. With increasing survival rates of cancer patients, the long(er)-term effects of anticancer treatment (i.e. cardiac toxicity) are receiving more scrutiny. In this context, the programme will conclude with highlighting academic research to evaluate the detrimental effects of many anticancer drugs on endothelial cells. Endothelial cells are the inner lining of the vascular system and play a pivotal role in vascular physiology and pathophysiology. At the end of the programme, students will have gained a comprehensive view of the topic of cardiovascular (patho)physiology and how these mechanisms should be taken into account and screened for during drug development.

Remarks

Successful completion of the summer school by attending all the lectures and participation in the oral examination can be awarded with 3 CREDITS according the European Credit Transfer System (ECTS).

To include the credits in the curriculum at the home institution, participants need an agreement with the responsible person at the home institution.

A certificate will be awarded at the end of the programme. All certificates of completion are issued as a micro-credential.